Steady-temperature Distribution of Tissue Embedded with Large Blood Vessels during Photo-thermal Therapy
نویسنده
چکیده
The large blood vessels would act as a heat sink and hence plays a significant role during photo-thermal therapy. Gold nanoshell was considered as an high heat absorbing agent in photo-thermal heating to reduce the cooling effect of large blood vessels. In this paper, the thermal history of tissue embedded with large blood vessels during photo-thermal heating were calculated using finite element based simulation technique. A volumetric laser source term based on modified Beer-Lambert law was introduced to take care of laser heating. The results obtained conclude that tissue with different orientation of blood vessels results in different thermal response at the tissue surface. In the later part of the study, gold nanoshells were introduced into the laser irradiated tissue to overcome the cooling effect of large blood vessels during photo-thermal therapy and also the effect of size and concentration of nanoparticles on tissue heating were analysed.
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